Development of a Gastroretentive Polyherbal Formulation and its Standardization

Pharmacognosy Research,2022,14,4,379-390.DOI:10.5530/pres.14.4.56Published:October 2022Type:Original ArticleAuthors:Manish Kumar Gupta, Medha Amol Khade, Birendra Srivastava, Supriya Rajesh Hyam, and Prashant Basappa Gurav Author(s) affiliations:Manish Gupta1, Khade2,*, Srivastava1, Hyam3, Gurav4 1School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, Rajasthan, INDIA. 2Research Scholar, School 3Vijayrao Naik College Pharmacy, Kankavali, Maharashtra, 4Department Pharmaceutics, Indira Institute Sadavali, Abstract:Background: Phytopharmaceuticals within the shape entire herb, plant parts, or separated bioactive constituents have been utilized broadly in therapeutics since antiquated times till date. The appealing use drugs natural root has driven requirement for standardization as per WHO guidelines. Objectives: main aim existing study was to formulate polyherbal gastroretentive capsules by using Carbopol 934 971P different concentration ranges get desired buoyancy rate. Materials Methods: prepared formulation characterized physico-chemical parameters pharmaceutical quality control tests. Standard procedures were used estimate organoleptic properties, extractive values, ash values crude formulations. Extraction carried out Soxhlation followed preliminary phytochemical evaluation HPTLC fingerprinting extracts. extracts formulated into a capsule assessed physical parameters. Results: assessment established presence flavonoids, alkaloids, saponins, steroids, glycosides. Rf obtained from studies signified important phytoconstituents such Shogaols, 6-Gingerol, 8-Gingerol, Glycyrrhizin, Andrographolides, Marmelosin, Conessine. Percent Carr’s consolidation index ranging 8.111 ± 0.157 8.827 0.186, Hausner’s ratio between 1.088 0.002 1.097 0.002, angle repose below 30 are indicative excellent flow property granules. Conclusion: PHF4 containing granules 75 mg showed effect more than 24 hr with structural integrity. Keywords:Extraction, fingerprinting, Polyherbal formulation, StandardizationView:PDF (1.63 MB)